IL2RB and IL15RA

Number of citations of the paper that reports this interaction (PubMedID 7641685)
153

Data Source:
HPRD (in vitro, in vivo)

		IL2RB	IL15RA
Description		interleukin 2 receptor subunit beta	interleukin 15 receptor subunit alpha
Image
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Integral Component Of Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane	Golgi Membrane Extracellular Space Endosome Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Vesicle Membrane Nuclear Membrane
	Molecular Function	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	Cytokine Receptor Activity Protein Binding Protein Kinase Binding Interleukin-15 Receptor Activity
	Biological Process	Signal Transduction Cytokine-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Phagocytosis Protein-containing Complex Assembly	Positive Regulation Of Natural Killer Cell Differentiation Interleukin-15-mediated Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		RAF/MAP kinase cascade Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Interleukin receptor SHC signaling	Interleukin-15 signaling Interleukin-15 signaling
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Asthma ( 20860503 32296059) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) L-selectin levels ( 25576479) Lack of premeditation ( 30718321) Mean corpuscular volume ( 27863252) Rheumatoid arthritis ( 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Tuberculosis ( 24057671) Type 1 diabetes ( 21829393)	Alopecia areata ( 25608926) Asthma ( 31959851 31619474) Asthma (bronchodilator response) ( 23508266) Atopic dermatitis ( 26482879) Blood protein levels ( 30072576 29875488 28240269) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 23128233) Medication use (thyroid preparations) ( 31015401) Neuroblastoma (pediatric) ( 32599975) Soluble interleukin-2 receptor subunit alpha ( 26293465)
Interacting Genes		32 interacting genes: CISH EIF3B FYN GRB2 HGS IL15 IL15RA IL2 IL2RA IL2RG JAK1 JAK3 LCK LYN MKKS MTDH ODF3B PIK3R1 PTPN6 RACK1 RAF1 SHB SHC1 SOCS1 SOCS3 SPIB STAT1 STAT3 STAT5A STAT5B SYK TRIP13	12 interacting genes: AXL BCL10 CASK CDK2 CDK4 IL15 IL2RB IL2RG PIAS4 RCVRN SYK TRAF2
Entrez ID		3560	3601
HPRD ID		00896	03045
Ensembl ID		ENSG00000100385	ENSG00000134470
Uniprot IDs		P14784	A0A0A0MS77 G8CVM3 Q13261
PDB IDs		1ILM 1ILN 2B5I 2ERJ 3QAZ 4GS7 5M5E 6E8K	2ERS 2Z3Q 2Z3R 4GS7
Enriched GO Terms of Interacting Partners?
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