IL3RA and GNA12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		IL3RA	GNA12
Description		interleukin 3 receptor subunit alpha	G protein subunit alpha 12
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Lateral Plasma Membrane Brush Border Membrane
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Protein Binding Cytokine Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Cytokine-mediated Signaling Pathway Cellular Response To Interleukin-3 Interleukin-3-mediated Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Response To Xenobiotic Stimulus Regulation Of Fibroblast Migration Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling	G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Sargramostim Tagraxofusp
Diseases
GWAS		Schizophrenia ( 17522711)	Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime sleep phenotypes ( 27126917) Eosinophil counts ( 32888494) Height ( 28552196 20881960 25282103 25429064 19343178 31562340 18391951 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Inflammatory bowel disease ( 28067908) Lateral ventricular volume in normal aging ( 30258056) Loneliness (linear analysis) ( 27629369) Medial thalamic nuclei volume ( 34006833) Monocyte count ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Schizophrenia x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Subcortical volume (MOSTest) ( 32665545) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 28067908 23128233 21297633) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412) Weight ( 28552196) White matter integrity ( 23218918)
Interacting Genes		32 interacting genes: BMP10 C2CD2L CDC25A CDK1 CISH CLDN19 CSF2 CSF2RB EMP3 FOXP1 GIMAP1 GNA12 IL3 JAGN1 JAK1 JAK2 LNX1 NINJ2 NR0B2 PAQR5 PPP1CC SAE1 SERP1 SGK2 SMAGP SYS1 TMEM128 TMEM147 TMEM254 TMEM65 TRARG1 VAMP5	30 interacting genes: ACTB AGTR1 AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 S1PR4 S1PR5 TBXA2R TEC TSHR
Entrez ID		3563	2768
HPRD ID		02392	05093
Ensembl ID		ENSG00000185291	ENSG00000146535
Uniprot IDs		P26951	E9PC54 Q03113 Q6ZQV4
PDB IDs		4JZJ 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?
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