RSPO4 and STK16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RSPO4	STK16
Description		R-spondin 4	serine/threonine kinase 16
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Nucleoplasm Cytoplasm Golgi Apparatus Golgi-associated Vesicle Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Heparin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Nail Development	Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		Regulation of FZD by ubiquitination
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576) Lean body mass ( 28552196) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		15 interacting genes: ANKRD11 DHX57 GNG13 GPSM3 GUCD1 HGS KLHL38 LGR4 MAPK9 MKRN3 PIH1D2 STK16 USP20 ZNF330 ZNF77	85 interacting genes: ADAMTSL4 AGR2 ARNT2 ATP23 BHLHA9 CALCOCO2 CBX3 CCDC33 CFP CRX CSKMT CSNK2B CYSRT1 DDIT4L DNAJA3 DRG1 EFEMP2 EFHC2 ELK1 FLACC1 FRS3 FXR1 GABPA IKZF3 INCA1 KCTD14 KCTD17 KLHL20 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP13-1 KRTAP13-2 KRTAP26-1 KRTAP6-3 MBP MEOX2 MGAT5B MIER3 MIIP MTUS2 NAA80 NAGK NBPF19 NIF3L1 NOTCH2NLA PCSK5 PKNOX2 PLA2G10 PLSCR1 PLSCR3 PRDM6 PRKAR1B PTH1R REL RFX6 RPIA RSPO4 SAXO1 SKIL SOCS2 SPRY2 SSC4D TCF12 TCF4 TLE5 TNFAIP1 TRAF3IP2 TRIM27 TRIM42 TRIP6 TUBA4A USP54 YPEL3 ZMAT1 ZNF330 ZNF343 ZNF774
Entrez ID		343637	8576
HPRD ID		18788	05281
Ensembl ID		ENSG00000101282	ENSG00000115661
Uniprot IDs		Q2I0M5	B4DPS1 B8ZZI5 O75716
PDB IDs			2BUJ
Enriched GO Terms of Interacting Partners?
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