BIRC3 and CD40

Number of citations of the paper that reports this interaction (PubMedID 11562359)
8

Data Source:
HPRD (in vitro)

		BIRC3	CD40
Description		baculoviral IAP repeat containing 3	CD40 molecule
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Membrane Raft	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface CD40 Receptor Complex Neuronal Cell Body Varicosity Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Antigen Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity
	Biological Process	Apoptotic Process Cell Surface Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Spermatogenesis Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Regulation Of Inflammatory Response Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity	Positive Regulation Of Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Inflammatory Response B Cell Mediated Immunity CD40 Signaling Pathway Platelet Activation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-12 Production Response To Cobalamin Response To Interferon-gamma TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Erythropoietin B Cell Proliferation B Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Protozoan Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Kinase C Signaling Response To Peptide Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR2 non-canonical NF-kB pathway Regulation of necroptotic cell death TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Ub-specific processing proteases IKK complex recruitment mediated by RIP1
Drugs			Lucatumumab Dacetuzumab
Diseases
GWAS		Prostate cancer ( 23535732) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)	Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 22446961 33106546 22446962) Multiple sclerosis ( 22190364 24076602 19525955 21833088) Rheumatoid arthritis ( 30423114 18794853 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469) Tonsillectomy ( 27182965 28928442)
Interacting Genes		42 interacting genes: BCL10 BIRC5 CASP3 CASP7 CASP9 CD40 CYFIP2 DIABLO DZIP3 FDX1 GLMN GSPT1 HAX1 HTRA2 IKBKE IKBKG MAP3K14 MBTPS1 PACS2 PELI1 RAF1 RCHY1 RIPK1 RIPK2 RIPK3 RIPK4 SNX7 SPHK1 SUMO1 TRAF1 TRAF2 TRAF3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2N UBE2Q2 UBE2V1 USP19 YOD1	49 interacting genes: BIRC2 BIRC3 CAV1 CBL CD40LG CMTM5 CMTM6 CYB561A3 DEFB121 EBP EMP1 FAF1 HSPA4 HSPA8 IL4R INSIG2 JAK3 MAL MAP3K8 MFSD5 MIP MS4A1 NCOA6 NELFCD NSMAF PIK3R1 PLP1 RIPK2 RPS5 SLC30A2 SLC30A3 SLC39A13 SLC7A1 TANK TDP2 TLCD1 TMEM107 TMEM128 TMEM147 TP53TG5 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 WFDC2 XRCC5 XRCC6
Entrez ID		330	958
HPRD ID		03426	00178
Ensembl ID		ENSG00000023445	ENSG00000101017
Uniprot IDs		Q13489	A0A0S2Z349 A0A0S2Z3C7 P25942 Q6P2H9
PDB IDs		2UVL 3EB5 3EB6 3M0A 3M0D	1CDF 1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL 6FAX 6PE8 6PE9
Enriched GO Terms of Interacting Partners?
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