CD40 and TMEM147

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CD40	TMEM147
Description		CD40 molecule	transmembrane protein 147
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface CD40 Receptor Complex Neuronal Cell Body Varicosity Intracellular Membrane-bounded Organelle Extracellular Exosome	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Antigen Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity	Protein Binding Ribosome Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Inflammatory Response B Cell Mediated Immunity CD40 Signaling Pathway Platelet Activation Positive Regulation Of B Cell Proliferation Positive Regulation Of Interleukin-12 Production Response To Cobalamin Response To Interferon-gamma TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Erythropoietin B Cell Proliferation B Cell Activation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Defense Response To Protozoan Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein-containing Complex Assembly Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Kinase C Signaling Response To Peptide Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
Drugs		Lucatumumab Dacetuzumab
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 22446961 33106546 22446962) Multiple sclerosis ( 22190364 24076602 19525955 21833088) Rheumatoid arthritis ( 30423114 18794853 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469) Tonsillectomy ( 27182965 28928442)	Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514)
Interacting Genes		49 interacting genes: BIRC2 BIRC3 CAV1 CBL CD40LG CMTM5 CMTM6 CYB561A3 DEFB121 EBP EMP1 FAF1 HSPA4 HSPA8 IL4R INSIG2 JAK3 MAL MAP3K8 MFSD5 MIP MS4A1 NCOA6 NELFCD NSMAF PIK3R1 PLP1 RIPK2 RPS5 SLC30A2 SLC30A3 SLC39A13 SLC7A1 TANK TDP2 TLCD1 TMEM107 TMEM128 TMEM147 TP53TG5 TRAF1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRAF6 WFDC2 XRCC5 XRCC6	55 interacting genes: ABHD16A ABI3 CD200 CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 DPM3 EBP EFNA4 ENPP4 F11R FFAR2 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PACC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC22A1 SLC22A2 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12
Entrez ID		958	10430
HPRD ID		00178	17633
Ensembl ID		ENSG00000101017	ENSG00000105677
Uniprot IDs		A0A0S2Z349 A0A0S2Z3C7 P25942 Q6P2H9	Q9BVK8
PDB IDs		1CDF 1CZZ 1D00 1FLL 1LB6 3QD6 5DMI 5DMJ 5IHL 6FAX 6PE8 6PE9	6W6L
Enriched GO Terms of Interacting Partners?
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