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CD40 and TRAF5
Number of citations of the paper that reports this interaction (PubMedID
8790348
)
64
Data Source:
HPRD
(two hybrid, in vitro)
CD40
TRAF5
Description
CD40 molecule
TNF receptor associated factor 5
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
CD40 Receptor Complex
Neuronal Cell Body
Varicosity
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Centrosome
Cytosol
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Plasma Membrane Signaling Receptor Complex
Molecular Function
Antigen Binding
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Identical Protein Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cellular Calcium Ion Homeostasis
Inflammatory Response
B Cell Mediated Immunity
CD40 Signaling Pathway
Platelet Activation
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Interleukin-12 Production
Response To Cobalamin
Response To Interferon-gamma
TRIF-dependent Toll-like Receptor Signaling Pathway
Cellular Response To Erythropoietin
B Cell Proliferation
B Cell Activation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Defense Response To Protozoan
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAP Kinase Activity
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Isotype Switching To IgG Isotypes
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Protein-containing Complex Assembly
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Protein Kinase C Signaling
Response To Peptide
Positive Regulation Of Endothelial Cell Apoptotic Process
Apoptotic Process
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Signal Transduction Involved In Regulation Of Gene Expression
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of JNK Cascade
MRNA Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein K63-linked Ubiquitination
Interleukin-17-mediated Signaling Pathway
Pathways
Drugs
Lucatumumab
Dacetuzumab
Diseases
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Chronic hepatitis B infection (
25802187
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Hodgkin's lymphoma (
30194254
)
Inflammatory bowel disease (
28067908
23128233
)
Kawasaki disease (
22446961
33106546
22446962
)
Multiple sclerosis (
22190364
24076602
19525955
21833088
)
Rheumatoid arthritis (
30423114
18794853
23143596
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Systemic lupus erythematosus (
28714469
)
Tonsillectomy (
27182965
28928442
)
Household income (MTAG) (
31844048
)
Interacting Genes
49 interacting genes:
BIRC2
BIRC3
CAV1
CBL
CD40LG
CMTM5
CMTM6
CYB561A3
DEFB121
EBP
EMP1
FAF1
HSPA4
HSPA8
IL4R
INSIG2
JAK3
MAL
MAP3K8
MFSD5
MIP
MS4A1
NCOA6
NELFCD
NSMAF
PIK3R1
PLP1
RIPK2
RPS5
SLC30A2
SLC30A3
SLC39A13
SLC7A1
TANK
TDP2
TLCD1
TMEM107
TMEM128
TMEM147
TP53TG5
TRAF1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRAF6
WFDC2
XRCC5
XRCC6
66 interacting genes:
BEX3
CAPNS1
CCDC184
CD27
CD40
CDC37
CIB3
COG7
COMMD3
DGKH
ENOX2
FAM9A
FBXO28
GAS8
GOLGA2
GORASP2
HOMER1
HSD17B10
HSF2BP
LMO4
LNX1
LTBR
MAP3K14
MAP3K5
MDM2
MEOX2
NMI
NTAQ1
NUMBL
ODF2
PIAS2
PIBF1
PICK1
PSMA1
RAD23A
RIPK1
RIPK2
RNF111
RNF4
SDCBP
SEC13
SERPINB9
SUMO1
TBK1
TDP2
THAP1
THAP7
TNFRSF11A
TNFRSF12A
TNFRSF13B
TNFRSF14
TNFRSF19
TNFRSF4
TNFRSF8
TRAF2
TRAF3
TRAF3IP2
TRAF6
TRIM27
TRIM37
TRIM8
UBC
USP7
YPEL5
ZFAND6
ZNF655
Entrez ID
958
7188
HPRD ID
00178
03834
Ensembl ID
ENSG00000101017
ENSG00000082512
Uniprot IDs
A0A0S2Z349
A0A0S2Z3C7
P25942
Q6P2H9
O00463
PDB IDs
1CDF
1CZZ
1D00
1FLL
1LB6
3QD6
5DMI
5DMJ
5IHL
6FAX
6PE8
6PE9
7L3L
Enriched GO Terms of Interacting Partners
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