HSBP1 and BRK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HSBP1	BRK1
Description		heat shock factor binding protein 1	BRICK1 subunit of SCAR/WAVE actin nucleating complex
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cytoskeleton Axon Cytoplasm	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Binding Identical Protein Binding	Protein Binding Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Axonal Transport Of Mitochondrion Endodermal Cell Differentiation Cellular Heat Acclimation	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Population Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		HSF1 activation Attenuation phase HSF1-dependent transactivation	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Lead levels ( 26025379) Metabolite levels ( 23823483) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)	Arterial stiffness index ( 31235810)
Interacting Genes		25 interacting genes: BLOC1S5 BRK1 CCHCR1 CD1B CYSRT1 GORASP2 HSF1 HSPA1A KIAA1217 KIFC3 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 LNX1 MPHOSPH6 MPP7 NOTCH2NLA RPL13 SDCBP SDCBP2 SDR42E1 WASHC1 WASHC3 ZBTB25	10 interacting genes: BRAP CYFIP2 HSBP1 MRFAP1 NCK1 NCKAP1 NDEL1 PFDN1 PIK3R3 WASF1
Entrez ID		3281	55845
HPRD ID		05185	12818
Ensembl ID		ENSG00000230989	ENSG00000254999
Uniprot IDs		O75506	Q8WUW1
PDB IDs		3CI9	3P8C 4N78
Enriched GO Terms of Interacting Partners?
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