H1-2 and KPNA7

Number of citations of the paper that reports this interaction (PubMedID 18258596)
53

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		H1-2	KPNA7
Description		H1.2 linker histone, cluster member	karyopherin subunit alpha 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleosome Euchromatin Nucleus Transcriptionally Active Chromatin	Nucleus Nucleoplasm Spindle Cytosol
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation	Blastocyst Development NLS-bearing Protein Import Into Nucleus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Histone H3-K27 Trimethylation
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS			Eosinophil counts ( 32888494) Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 28067908) Lack of premeditation ( 30718321) Ulcerative colitis ( 28067908 20228798) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		29 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 HELLS IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12 YBX1	2 interacting genes: H1-2 TWIST1
Entrez ID		3006	402569
HPRD ID		07514	19598
Ensembl ID		ENSG00000187837	ENSG00000185467
Uniprot IDs		P16403	A9QM74
PDB IDs
Enriched GO Terms of Interacting Partners?
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