H1-2 and KPNB1

Number of citations of the paper that reports this interaction (PubMedID 18258596)
53

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		H1-2	KPNB1
Description		H1.2 linker histone, cluster member	karyopherin subunit beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Euchromatin Nucleus Transcriptionally Active Chromatin	Extracellular Region Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Nuclear Membrane Specific Granule Lumen Extracellular Exosome Endoplasmic Reticulum Tubular Network Ficolin-1-rich Granule Lumen
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	RNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Small GTPase Binding Hsp90 Protein Binding Nuclear Import Signal Receptor Activity Importin-alpha Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Astral Microtubule Organization Ran Protein Signal Transduction Establishment Of Mitotic Spindle Localization Establishment Of Protein Localization Mitotic Spindle Assembly
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Regulation of cholesterol biosynthesis by SREBP (SREBF) Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Nuclear import of Rev protein Nuclear import of Rev protein Initiation of Nuclear Envelope (NE) Reformation Neutrophil degranulation Postmitotic nuclear pore complex (NPC) reformation Inhibition of nitric oxide production
Drugs
Diseases
GWAS			Asthma ( 31619474) Body mass index ( 26426971) Glycine levels ( 30837465) HDL cholesterol ( 30275531) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (HMG CoA reductase inhibitors) ( 31015401) Multiple sclerosis ( 22190364) Optic cup area ( 25631615) Simvastatin-induced myopathy ( 31220337) Total cholesterol levels ( 33339817) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		29 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 HELLS IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12 YBX1	69 interacting genes: AMFR CD99 CHD3 CRBN CSE1L CSNK1A1 CUL4B ELAVL1 EPAS1 EXO1 FGFR1 H1-0 H1-2 IGFBP3 IGFBP5 IPO7 IPO8 ITCH KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LINC01554 LYST MESD MSL1 MTNR1A NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 OGT PIAS4 PLCD1 PRKD3 PTEN PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RBX1 RPL5 RUNX1T1 SELENOS SENP2 SMAD2 SMAD3 SMN1 SMNDC1 SNAI1 SNAPIN SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5
Entrez ID		3006	3837
HPRD ID		07514	04114
Ensembl ID		ENSG00000187837	ENSG00000108424
Uniprot IDs		P16403	B7Z752 Q14974
PDB IDs			1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW 3W5K 6N88 6N89
Enriched GO Terms of Interacting Partners?
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