RACGAP1 and KIF23

Number of citations of the paper that reports this interaction (PubMedID 32203420)
21

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RACGAP1	KIF23
Description		Rac GTPase activating protein 1	kinesin family member 23
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GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Spindle Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex	Nucleus Nucleoplasm Centrosome Spindle Cytosol Kinesin Complex Microtubule Focal Adhesion Midbody Mitotic Spindle Flemming Body Centralspindlin Complex
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Spermatogenesis Neuroblast Proliferation Sulfate Transport Positive Regulation Of Cytokinesis Intracellular Signal Transduction Regulation Of Embryonic Development Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Mitotic Spindle Elongation Mitotic Cytokinesis Microtubule-based Movement Positive Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RAC3 GTPase cycle Kinesins	MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Mitotic Telophase/Cytokinesis Kinesins
Drugs
Diseases
GWAS			Mean reticulocyte volume ( 32888494) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	14 interacting genes: ACTA1 ARF3 CLK1 LATS2 NMB PLK1 PPP1CB RACGAP1 RBM34 SUMO2 USP8 YWHAB YWHAG YWHAQ
Entrez ID		29127	9493
HPRD ID		05402	05455
Ensembl ID		ENSG00000161800	ENSG00000137807
Uniprot IDs		A0A024R136 B2RE34 Q9H0H5	Q02241
PDB IDs		2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K	3VHX
Enriched GO Terms of Interacting Partners?
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