RACGAP1 and MAP3K4

Number of citations of the paper that reports this interaction (PubMedID 9079650)
67

Data Source:
HPRD (in vitro)

		RACGAP1	MAP3K4
Description		Rac GTPase activating protein 1	mitogen-activated protein kinase kinase kinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Spindle Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Spermatogenesis Neuroblast Proliferation Sulfate Transport Positive Regulation Of Cytokinesis Intracellular Signal Transduction Regulation Of Embryonic Development Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore	MAPK Cascade Placenta Development Protein Phosphorylation Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Telomerase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Telomere Capping
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RAC3 GTPase cycle Kinesins
Drugs			Fostamatinib
Diseases
GWAS			Aging ( 22773346) Blood protein levels ( 28240269) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)
Interacting Genes		32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	27 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 EPHB4 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ
Entrez ID		29127	4216
HPRD ID		05402	03886
Ensembl ID		ENSG00000161800	ENSG00000085511
Uniprot IDs		A0A024R136 B2RE34 Q9H0H5	Q9P1M2 Q9Y6R4
PDB IDs		2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?