RACGAP1 and MPRIP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		RACGAP1	MPRIP
Description		Rac GTPase activating protein 1	myosin phosphatase Rho interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Spindle Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex	Cytosol Focal Adhesion Actin Cytoskeleton
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Spermatogenesis Neuroblast Proliferation Sulfate Transport Positive Regulation Of Cytokinesis Intracellular Signal Transduction Regulation Of Embryonic Development Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Actin Filament Organization
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RAC3 GTPase cycle Kinesins	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS			Diabetic retinopathy ( 21441570) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Hemoglobin ( 32888494) Obesity-related traits ( 23251661)
Interacting Genes		32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	16 interacting genes: ATXN7 COL6A1 IKBKG LSM8 NOS3 PIAS4 PPP1R12A PPP1R12C PTEN RACGAP1 RHOA SMARCA2 YTHDC1 YWHAB YWHAG YWHAQ
Entrez ID		29127	23164
HPRD ID		05402	17591
Ensembl ID		ENSG00000161800	ENSG00000133030
Uniprot IDs		A0A024R136 B2RE34 Q9H0H5	Q6WCQ1 Q8N236
PDB IDs		2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K
Enriched GO Terms of Interacting Partners?
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