GPI and IGFBP3

Number of citations of the paper that reports this interaction (PubMedID 15059907)
9

Data Source:
HPRD (in vitro)

		GPI	IGFBP3
Description		glucose-6-phosphate isomerase	insulin like growth factor binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytosol Plasma Membrane Membrane Secretory Granule Lumen Neuron Projection Ciliary Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex
	Molecular Function	Glucose-6-phosphate Isomerase Activity Cytokine Activity Protein Binding Growth Factor Activity Ubiquitin Protein Ligase Binding Monosaccharide Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Mesoderm Formation Positive Regulation Of Immunoglobulin Production Carbohydrate Metabolic Process Gluconeogenesis Glycolytic Process Humoral Immune Response Signal Transduction Hemostasis Learning Or Memory Positive Regulation Of Endothelial Cell Migration Response To Estradiol Response To Progesterone Response To Testosterone Erythrocyte Homeostasis Response To Immobilization Stress Response To Muscle Stretch Glucose Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Morphine Negative Regulation Of Neuron Apoptotic Process Response To Cadmium Ion Glucose 6-phosphate Metabolic Process	Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Apoptotic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Catalytic Activity
Pathways		TP53 Regulates Metabolic Genes Neutrophil degranulation Glycolysis Gluconeogenesis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation
Drugs		alpha-D-glucose 6-phosphate 6-phospho-D-gluconic acid 5-phospho-D-arabinohydroxamic acid D-glucitol 6-phosphate 5-Phosphoarabinonic Acid Glucose-6-Phosphate D-erythrose 4-phosphate Fructose-6-phosphate Copper Artenimol	Alitretinoin Mecasermin
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular volume ( 32888494)	Birth weight ( 31043758) Blood pressure traits (multi-trait analysis) ( 28498854) Blood protein levels ( 30072576 29875488 23696881) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 27841878 28498854 30578418) FEV1 ( 30804560) Height ( 25282103 31562340 33713608) Hypospadias ( 25108383) Insulin-like growth factors ( 21216879) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 26390057 28135244 27841878 29403010 28739976 27618448 28498854 30487518) QRS duration ( 27577874 21076409) Rosacea symptom severity ( 29771307) Sitting height ratio ( 25865494) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27841878 27618447 27618448) Tonsillectomy ( 27182965 28928442) Venous thromboembolism ( 26888256) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: AMFR CSNK2A1 DCC IGFBP3 LINC01554 PARP14 PCNA	39 interacting genes: ADAM12 AURKA BMPR1A BUB1 CAV1 CCND1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FBXW7 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 KRAS LTBP1 MLH3 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 PPARG RAD54B RXRA STK11 TF WDR5
Entrez ID		2821	3486
HPRD ID		01394	00899
Ensembl ID		ENSG00000105220	ENSG00000146674
Uniprot IDs		A0A2U3TZU2 B4DE36 P06744	B3KPF0 P17936
PDB IDs		1IAT 1IRI 1JIQ 1JLH 1NUH 6XUH 6XUI
Enriched GO Terms of Interacting Partners?
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