IGFBP3 and LTBP1

Number of citations of the paper that reports this interaction (PubMedID 12962157)
10

Data Source:
HPRD (two hybrid)

		IGFBP3	LTBP1
Description		insulin like growth factor binding protein 3	latent transforming growth factor beta binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex	Microfibril Extracellular Region Endoplasmic Reticulum Lumen Extracellular Matrix Protein-containing Complex Collagen-containing Extracellular Matrix
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding	Transforming Growth Factor Beta-activated Receptor Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Transforming Growth Factor Beta Binding Microfibril Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Apoptotic Process Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Catalytic Activity	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Sequestering Of TGFbeta In Extracellular Matrix Regulation Of Transforming Growth Factor Beta Activation
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TP53 Regulates Transcription of Death Receptors and Ligands Post-translational protein phosphorylation	Molecules associated with elastic fibres Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Alitretinoin Mecasermin
Diseases
GWAS		Birth weight ( 31043758) Blood pressure traits (multi-trait analysis) ( 28498854) Blood protein levels ( 30072576 29875488 23696881) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 27841878 28498854 30578418) FEV1 ( 30804560) Height ( 25282103 31562340 33713608) Hypospadias ( 25108383) Insulin-like growth factors ( 21216879) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Male-pattern baldness ( 27182965) Molybdenum levels ( 26025379) Night sleep phenotypes ( 27126917) Offspring birth weight ( 31043758) Poor prognosis in Crohn's disease ( 28067912) Pulse pressure ( 26390057 28135244 27841878 29403010 28739976 27618448 28498854 30487518) QRS duration ( 27577874 21076409) Rosacea symptom severity ( 29771307) Sitting height ratio ( 25865494) Subjective response to lithium treatment in bipolar disorder ( 26503763) Systolic blood pressure ( 27841878 27618447 27618448) Tonsillectomy ( 27182965 28928442) Venous thromboembolism ( 26888256) Waist circumference adjusted for body mass index ( 34021172)	Arthritis (juvenile idiopathic) ( 34101054) Carpal tunnel syndrome ( 30833571) Central corneal thickness ( 32528159 29760442) Diverticular disease ( 30177863) Height ( 28552196 20881960 25282103 25429064 19893584 23563607 31562340 20189936) Hip circumference adjusted for BMI ( 34021172 25673412) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Immune response to smallpox vaccine (IL-6) ( 22610502) Intraocular pressure ( 29617998 29785010 29235454) Knee osteoarthritis ( 30374069) Male-pattern baldness ( 28196072) Optic disc size ( 31809533) Rosacea symptom severity ( 29771307) Total cholesterol levels ( 33339817) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500)
Interacting Genes		39 interacting genes: ADAM12 AURKA BMPR1A BUB1 CAV1 CCND1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FBXW7 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 KRAS LTBP1 MLH3 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 PPARG RAD54B RXRA STK11 TF WDR5	16 interacting genes: ATN1 CACNA1A CAD FBN1 FBN2 FN1 FOXN2 HOXA1 HTRA1 IGFBP3 IGFBP5 ITGB5 NOTCH3 TGFB1 TGM2 ZFP36L2
Entrez ID		3486	4052
HPRD ID		00899	01039
Ensembl ID		ENSG00000146674	ENSG00000049323
Uniprot IDs		B3KPF0 P17936	B7ZLY3 Q14766
PDB IDs			1KSQ
Enriched GO Terms of Interacting Partners?
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