SIGLEC7 and SMIM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SIGLEC7	SMIM1
Description		sialic acid binding Ig like lectin 7	small integral membrane protein 1 (Vel blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Protein Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity	Protein Binding Protein Homodimerization Activity
	Biological Process	Cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		N-acetyl-alpha-D-glucosamine
Diseases
GWAS		Blood protein levels ( 29875488) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Glycated hemoglobin levels ( 34059833) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		5 interacting genes: GRB2 LGALS3BP PTPN11 SMIM1 TRAF4	56 interacting genes: ANKS6 AQP6 ASZ1 BCL2L13 BIK CD74 CISD2 COMT CREB3L1 CYB561 EBP ERGIC3 FAM174A FAM209A FAM210B FCER1G FFAR2 FNDC9 GJA8 GJB5 HACD2 HSD17B13 ICAM3 JAGN1 KIR2DL3 LHFPL5 LRP10 LRRC4C MFF MFSD6 MUC1 NAALAD2 NDUFAF2 PVR REEP4 RELL2 RETREG3 SAR1A SCN3B SDC3 SIGLEC7 SLC10A6 SLC18A1 SLC26A11 STING1 STX1A TM4SF19 TMEM154 TMEM31 TMEM45B TMEM51 TMEM52B TMEM86B TMPRSS2 TMX2 ZDHHC15
Entrez ID		27036	388588
HPRD ID		05102
Ensembl ID		ENSG00000168995	ENSG00000235169
Uniprot IDs		Q9Y286	B2RUZ4 M4WDD3
PDB IDs		1NKO 1O7S 1O7V 2DF3 2G5R 2HRL
Enriched GO Terms of Interacting Partners?
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