GDF2 and ACVR2B

Number of citations of the paper that reports this interaction (PubMedID 22718755)
73

Data Source:
BioGRID (pull down)

		GDF2	ACVR2B
Description		growth differentiation factor 2	activin A receptor type 2B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Activin-activated Receptor Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Ossification Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Osteoblast Differentiation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Cellular Iron Ion Homeostasis Negative Regulation Of DNA Replication Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Interleukin-8 Production Activin Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Cartilage Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Negative Regulation Of DNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis
Pathways		Signaling by BMP	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 30224653)	Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31152163 31015462) P wave duration ( 24850809)
Interacting Genes		6 interacting genes: ACVR1 ACVR2A ACVR2B ACVRL1 BMPR2 ENG	22 interacting genes: ACVR1B BMP10 BMP2 BMP7 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NODAL SNX1 SNX2 SNX6 SYNJ2BP TDGF1 TGFBRAP1 WNT5A
Entrez ID		2658	93
HPRD ID		05492	04106
Ensembl ID		ENSG00000263761	ENSG00000114739
Uniprot IDs		B2RC63 Q9UK05	Q13705
PDB IDs		1ZKZ 4FAO 4MPL 4YCG 4YCI 5HZW 5I05	2H62 2QLU 4FAO 5NGV 5NHR
Enriched GO Terms of Interacting Partners?
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