GDF2

Description		growth differentiation factor 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity
	Biological Process	Ossification Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Osteoblast Differentiation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Cellular Iron Ion Homeostasis Negative Regulation Of DNA Replication Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Interleukin-8 Production Activin Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Cartilage Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Negative Regulation Of DNA Biosynthetic Process
Pathways		Signaling by BMP
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 30224653)
Interacting Genes		6 interacting genes: ACVR1 ACVR2A ACVR2B ACVRL1 BMPR2 ENG
Entrez ID		2658
HPRD ID		05492
Ensembl ID		ENSG00000263761
Uniprot IDs		B2RC63 Q9UK05
PDB IDs		1ZKZ 4FAO 4MPL 4YCG 4YCI 5HZW 5I05
Enriched GO Terms of Interacting Partners?
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