GDF2 and ENG

Number of citations of the paper that reports this interaction (PubMedID 17311849)
201

Data Source:
BioGRID (pull down)

		GDF2	ENG
Description		growth differentiation factor 2	endoglin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Body Receptor Complex Endothelial Microparticle
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity	Transmembrane Signaling Receptor Activity Transforming Growth Factor Beta-activated Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Coreceptor Activity Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Identical Protein Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding
	Biological Process	Ossification Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Osteoblast Differentiation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Cellular Iron Ion Homeostasis Negative Regulation Of DNA Replication Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Interleukin-8 Production Activin Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Cartilage Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Negative Regulation Of DNA Biosynthetic Process	Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Epithelial To Mesenchymal Transition Positive Regulation Of Protein Phosphorylation Heart Looping Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Regulation Of Transcription, DNA-templated Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Protein Autophosphorylation Response To Corticosteroid Positive Regulation Of Collagen Biosynthetic Process Dorsal Aorta Morphogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Protein Kinase B Signaling Atrial Cardiac Muscle Tissue Morphogenesis Bone Development Extracellular Matrix Constituent Secretion Cellular Response To Mechanical Stimulus Endocardial Cushion To Mesenchymal Transition Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Atrioventricular Canal Morphogenesis Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Signaling by BMP
Drugs			Carotuximab
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 30224653)	Blood protein levels ( 30072576) Body mass index ( 26426971) Metabolic syndrome ( 20694148) Monocyte count ( 32888494)
Interacting Genes		6 interacting genes: ACVR1 ACVR2A ACVR2B ACVRL1 BMPR2 ENG	16 interacting genes: ACVR1 ACVR2A BMP2 BMP7 CNTRL DYNLT4 GDF2 INHBA LHX2 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 TRAF1
Entrez ID		2658	2022
HPRD ID		05492	00565
Ensembl ID		ENSG00000263761	ENSG00000106991
Uniprot IDs		B2RC63 Q9UK05	A0A024R878 B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0
PDB IDs		1ZKZ 4FAO 4MPL 4YCG 4YCI 5HZW 5I05	5HZV 5HZW 5I04
Enriched GO Terms of Interacting Partners?
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