SPAG8 and TSC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPAG8	TSC1
Description		sperm associated antigen 8	TSC complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Spindle Membrane	Nucleus Cytoplasm Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Growth Cone Protein-containing Complex TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm Chaperone Complex
	Molecular Function	Molecular_function Protein Binding Microtubule Binding	Protein Binding Hsp70 Protein Binding GTPase Activating Protein Binding ATPase Inhibitor Activity Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Cell Cycle Spermatogenesis Single Fertilization Biological_process Cell Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell-matrix Adhesion Negative Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Neuron Projection Development Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATPase Activity Response To Insulin Negative Regulation Of GTPase Activity Myelination Memory T Cell Differentiation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Cellular Response To Oxygen-glucose Deprivation Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways			Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545)	Migraine without aura ( 23793025) Psoriasis ( 19169254)
Interacting Genes		88 interacting genes: ARMC5 B9D2 BATF2 C19orf54 CARM1 CCDC120 CCNC CDC23 CFP CSTF2 CSTF2T CTAG1A CTAG1B DMRT3 DOK3 DTX2 DYNLL2 EGFL7 FAM168B GIGYF1 GLYCTK GPSM3 HR INCA1 INTS11 JMJD4 KDM3B KLHL32 KRT34 KRTAP10-8 KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP26-1 KRTAP3-1 KRTAP6-2 KRTAP7-1 LASP1 MEOX1 METTL15 MGAT5B NEDD4L NHLRC4 NSD3 NUDT21 PATZ1 PEF1 PFDN5 PHF1 PITX1 PLA2G10 PRMT1 PRMT2 PRMT5 PRR35 RAN RBP3 RIPK4 RNF125 RUSC1 SERGEF SIGMAR1 SMUG1 SMYD1 SNRPB SNRPC SYNGAP1 TEKT3 TEKT5 TENT5B TRIB3 TRIM42 TSC1 TTC23 UBAP2 UBQLN1 UBQLN4 USP2 VPS37C YPEL3 ZBTB32 ZIC1 ZNF34 ZNF581	179 interacting genes: ABI1 ACTN1 ACTN2 AKT1 ANKIB1 ANKRD24 ANKRD35 APPL2 AQP1 ARAF ARID5A ATN1 ATXN1 AURKA AXIN1 BAG3 BCL11A BECN1 BEND5 BRD3 C1orf94 CALCOCO2 CAPZA2 CASC3 CCDC120 CCDC88B CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CDR2 CHCHD2 CNIH1 CNTRL CNTROB COG6 CSTF2 CTNNB1 DACH2 DCTN2 DMRT3 DOK5 EIF3A ENKD1 EZR FAM110A FAM222B FBF1 FCN1 FGFR4 FOLR2 FOXH1 FRS3 GCC1 GEMIN8 GFAP GLIS2 GOLGA2 GPANK1 GPATCH1 HECW1 HGS HNRNPM HOMER3 HOOK2 HOXC8 HR HSH2D ICA1 IGFN1 IKBKB KANSL2 KAT2A KAZN KDM1A KIF1C KIF5A KLC1 KLC4 LATS2 LENG1 LMO2 LRSAM1 LUC7L LZTS2 MAP2K5 MAPK14 MBIP MBP MSANTD3 MSN MT-ND1 MYC MYLIP MYOZ3 NDUFA9 NECAB2 NEFL NF2 NINL NKD2 NRBF2 PAEP PATL1 PATZ1 PHLDB1 PICK1 PITX1 PLK1 PLK2 POGZ POU6F2 PPFIA2 PPP1R18 PPP1R32 PRMT6 PTPA RALYL RASSF1 RBPMS RDX RHEB RIN1 RIN3 RUNDC3A SAMD11 SAMD7 SCMH1 SEC31A SELENOW SERTAD1 SH2D2A SHANK1 SHC3 SLC16A6 SMG9 SORBS3 SOX4 SPAG5 SPAG8 SUOX TANK TBC1D7 TBX6 TCF7L2 TFAP2D TFIP11 TLE5 TNS2 TRAF2 TRIM3 TRIOBP TSC2 TSGA10IP TSHZ3 TUBB4B VENTX VEZF1 VGLL3 VIM VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF423 ZNF587 ZNF765 ZNF79
Entrez ID		26206	7248
HPRD ID		12039	05594
Ensembl ID		ENSG00000137098	ENSG00000165699
Uniprot IDs		A0A140VJV0 Q99932	A0A2R8Y5S3 Q32NF0 Q86WV8 Q92574 X5D9D2
PDB IDs			4Z6Y 5EJC 7DL2
Enriched GO Terms of Interacting Partners?
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