SPAG8 and SERGEF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPAG8	SERGEF
Description		sperm associated antigen 8	secretion regulating guanine nucleotide exchange factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Spindle Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Molecular_function Protein Binding Microtubule Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Cell Cycle Spermatogenesis Single Fertilization Biological_process Cell Differentiation Positive Regulation Of Protein Binding Positive Regulation Of Transcription By RNA Polymerase II	Signal Transduction Negative Regulation Of Protein Secretion Regulation Of Catalytic Activity
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545)	Alcohol consumption (drinks per week) ( 30643258) Bipolar disorder ( 34099189) Body mass index ( 26426971)
Interacting Genes		88 interacting genes: ARMC5 B9D2 BATF2 C19orf54 CARM1 CCDC120 CCNC CDC23 CFP CSTF2 CSTF2T CTAG1A CTAG1B DMRT3 DOK3 DTX2 DYNLL2 EGFL7 FAM168B GIGYF1 GLYCTK GPSM3 HR INCA1 INTS11 JMJD4 KDM3B KLHL32 KRT34 KRTAP10-8 KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP26-1 KRTAP3-1 KRTAP6-2 KRTAP7-1 LASP1 MEOX1 METTL15 MGAT5B NEDD4L NHLRC4 NSD3 NUDT21 PATZ1 PEF1 PFDN5 PHF1 PITX1 PLA2G10 PRMT1 PRMT2 PRMT5 PRR35 RAN RBP3 RIPK4 RNF125 RUSC1 SERGEF SIGMAR1 SMUG1 SMYD1 SNRPB SNRPC SYNGAP1 TEKT3 TEKT5 TENT5B TRIB3 TRIM42 TSC1 TTC23 UBAP2 UBQLN1 UBQLN4 USP2 VPS37C YPEL3 ZBTB32 ZIC1 ZNF34 ZNF581	8 interacting genes: DPH3 EXOC2 FOXH1 HGS KDM1A PITX1 PRMT6 SPAG8
Entrez ID		26206	26297
HPRD ID		12039	06926
Ensembl ID		ENSG00000137098	ENSG00000129158
Uniprot IDs		A0A140VJV0 Q99932	A8K8C1 Q9UGK8
PDB IDs
Enriched GO Terms of Interacting Partners?
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