ALPL and PCSK6

		ALPL	PCSK6
Description		alkaline phosphatase, biomineralization associated	proprotein convertase subtilisin/kexin type 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrial Intermembrane Space Plasma Membrane Membrane Extracellular Matrix Anchored Component Of Membrane Mitochondrial Membrane Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Alkaline Phosphatase Activity Protein Binding Pyrophosphatase Activity Metal Ion Binding Phosphoamidase Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Nerve Growth Factor Binding
	Biological Process	Skeletal System Development Osteoblast Differentiation Endochondral Ossification Developmental Process Involved In Reproduction Dephosphorylation Response To Lipopolysaccharide Response To Vitamin D Response To Antibiotic Response To Glucocorticoid Cellular Response To Organic Cyclic Compound Cementum Mineralization	Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Regulation Of Lipoprotein Lipase Activity
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes
Drugs		Mersalyl
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) B6 vitamer levels (multivariate analysis) ( 30583557) Blood metabolite ratios ( 24816252) Calcific aortic valve stenosis ( 32141789) Folate pathway vitamin levels ( 19303062 19744961) Heel bone mineral density ( 30598549) Hematological and biochemical traits ( 20139978) Kidney stones ( 26272126 31729369) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic traits ( 21886157) Metabolite levels ( 23823483) Phosphorus levels ( 29403010 20558539) Plasma pyridoxal phosphate to pyridoxal ratio ( 31641590) Pyridoxal 5'-phosphate levels ( 25972531 31641590) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Serum alkaline phosphatase levels ( 33547301 31666285 29403010 33339817) Serum metabolite levels ( 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urolithiasis ( 30975718) Vitamin B levels in ischemic stroke ( 25147783)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)
Interacting Genes		7 interacting genes: ALOX5 EEF1A1 MAP3K14 PCSK6 SRPK2 TRAF2 TRAF3	12 interacting genes: ALPL CACNA1A FLG FN3K IGF1R IL16 PCSK5 PMCH RCN3 SNRPA1 SYNM ZNF441
Entrez ID		249	5046
HPRD ID		01377	01329
Ensembl ID		ENSG00000162551	ENSG00000140479
Uniprot IDs		A0A024RAB4 P05186	A2RQD9 H7BXT3 P29122 Q59H04
PDB IDs
Enriched GO Terms of Interacting Partners?
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