PCSK6 and PMCH

Number of citations of the paper that reports this interaction (PubMedID 10037747)
8

Data Source:
HPRD (in vivo, in vitro)

		PCSK6	PMCH
Description		proprotein convertase subtilisin/kexin type 6	pro-melanin concentrating hormone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Plasma Membrane Cell Surface Membrane Collagen-containing Extracellular Matrix	Extracellular Region Nucleus Synapse
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Nerve Growth Factor Binding	Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding
	Biological Process	Zygotic Determination Of Anterior/posterior Axis, Embryo Determination Of Left/right Symmetry Glycoprotein Metabolic Process Protein Processing Peptide Hormone Processing Regulation Of BMP Signaling Pathway Nerve Growth Factor Production Secretion By Cell Regulation Of Lipoprotein Lipase Activity	Neuropeptide Signaling Pathway Chemical Synaptic Transmission Spermatogenesis Behavior Feeding Behavior Cell Differentiation
Pathways		Signaling by NODAL NGF processing Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Handedness in dyslexia ( 21051773) Height ( 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Platelet-derived growth factor BB levels ( 27989323) Red blood cell count ( 32888494) Relative hand skill in reading disability ( 24068947) Severe coronary stenosis (young age of onset interaction) ( 33766035) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Tuberculosis ( 30713548) Type 2 diabetes ( 30470734)	Adventurousness ( 30643258) Brain morphology (MOSTest) ( 32665545) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)
Interacting Genes		12 interacting genes: ALPL CACNA1A FLG FN3K IGF1R IL16 PCSK5 PMCH RCN3 SNRPA1 SYNM ZNF441	10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		5046	5367
HPRD ID		01329	01459
Ensembl ID		ENSG00000140479	ENSG00000183395
Uniprot IDs		A2RQD9 H7BXT3 P29122 Q59H04	P20382
PDB IDs
Enriched GO Terms of Interacting Partners?
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