SUZ12 and AEBP2

Number of citations of the paper that reports this interaction (PubMedID 15225548)
315

Data Source:
HPRD (in vitro)

		SUZ12	AEBP2
Description		SUZ12 polycomb repressive complex 2 subunit	AE binding protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body ESC/E(Z) Complex	Chromatin Nucleoplasm ESC/E(Z) Complex
	Molecular Function	Transcription Corepressor Binding Protein Binding Enzyme Activator Activity Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding	DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Metal Ion Binding
	Biological Process	Spinal Cord Development Response To Retinoic Acid Negative Regulation Of Chemokine Production Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Catalytic Activity Histone H3-K27 Trimethylation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Transcription By RNA Polymerase II
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis	PRC2 methylates histones and DNA PKMTs methylate histone lysines
Drugs
Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)	Body size at age 10 ( 32376654) Chronic mountain sickness ( 31417607) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Height ( 28552196) Lung function (FEV1/FVC) ( 30804560) Manganese levels ( 26025379) Obesity-related traits ( 23251661) Opioid use cessation ( 31936517) Pulmonary function ( 21946350) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189)
Interacting Genes		25 interacting genes: AEBP2 ARHGAP5 BCL11A CDK19 CDK5R1 CDK8 CREB1 EZH2 H1-1 H3-4 KLRC1 LATS2 MED17 MED6 NOL4 NR1D1 PAXIP1 PJA1 PLA2G2A PRDM14 RBBP4 SLC2A2 TBC1D29P UBE2I WDR77	18 interacting genes: APP EED H1-1 H1-2 HMBOX1 JMJD6 KRTAP10-8 LDOC1 MDFI PICK1 RALYL RBBP4 SUZ12 THAP1 TRIM55 TRIM63 TSPYL2 ZNF408
Entrez ID		23512	121536
HPRD ID		06949	16477
Ensembl ID		ENSG00000178691	ENSG00000139154
Uniprot IDs		J3QQW9 Q15022	Q6ZN18
PDB IDs		4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3 6WKR 7AT8 7KSO 7KSR 7KTP	5WAI 5Y0U 5Y1U 6C23 6C24 6WKR 7KSO
Enriched GO Terms of Interacting Partners?
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