SUZ12 and SLC2A2

		SUZ12	SLC2A2
Description		SUZ12 polycomb repressive complex 2 subunit	solute carrier family 2 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body ESC/E(Z) Complex	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Cell-cell Junction Membrane Apical Plasma Membrane
	Molecular Function	Transcription Corepressor Binding Protein Binding Enzyme Activator Activity Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding	Fructose Transmembrane Transporter Activity Glucose Transmembrane Transporter Activity Hexose Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Spinal Cord Development Response To Retinoic Acid Negative Regulation Of Chemokine Production Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Catalytic Activity Histone H3-K27 Trimethylation	Carbohydrate Metabolic Process Fructose Transmembrane Transport Dehydroascorbic Acid Transport Glucose Transmembrane Transport
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis	Cellular hexose transport Regulation of gene expression in beta cells Regulation of insulin secretion Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) Intestinal hexose absorption
Drugs			Streptozocin
Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)	Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Blood sugar levels ( 29403010) C-reactive protein levels ( 30388399) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679 34059833) Fasting plasma glucose ( 28270201) Gamma glutamyl transferase levels ( 33339817) Glycated hemoglobin levels ( 34059833 28898252) Hemoglobin A1c levels ( 29403010) Homeostasis model assessment of beta-cell function ( 20081858) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Night sleep phenotypes ( 27126917) Response to metformin in type 2 diabetes (HbA1c reduction) ( 27500523) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 30297969 32499647)
Interacting Genes		25 interacting genes: AEBP2 ARHGAP5 BCL11A CDK19 CDK5R1 CDK8 CREB1 EZH2 H1-1 H3-4 KLRC1 LATS2 MED17 MED6 NOL4 NR1D1 PAXIP1 PJA1 PLA2G2A PRDM14 RBBP4 SLC2A2 TBC1D29P UBE2I WDR77	5 interacting genes: APP KPNA2 PDX1 PRKACA SUZ12
Entrez ID		23512	6514
HPRD ID		06949	00685
Ensembl ID		ENSG00000178691	ENSG00000163581
Uniprot IDs		J3QQW9 Q15022	P11168 Q6PAU8
PDB IDs		4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3 6WKR 7AT8 7KSO 7KSR 7KTP
Enriched GO Terms of Interacting Partners?
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