FNTA and INHBB

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		FNTA	INHBB
Description		farnesyltransferase, CAAX box, alpha	inhibin subunit beta B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Acetylcholine Receptor Regulator Activity Receptor Tyrosine Kinase Binding Alpha-tubulin Binding	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Protein Farnesylation Protein Geranylgeranylation Neurotransmitter Receptor Metabolic Process Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Deacetylase Activity	Ovarian Follicle Development Defense Response Cellular Response To Starvation Response To Wounding Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Negative Regulation Of Hepatocyte Growth Factor Production Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Cellular Response To Leptin Stimulus Adhesion Of Symbiont To Host Cell Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Oocyte Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Apoptotic cleavage of cellular proteins Inactivation, recovery and regulation of the phototransduction cascade RAS processing	Signaling by Activin Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin
Drugs		AZD3409 Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Zinc levels ( 26025379)	Age-related macular degeneration ( 23326517) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 22747683 27182965) Obesity ( 21552555) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31985003 23263486)
Interacting Genes		20 interacting genes: ACVR1 AP4M1 CENPF FNTB GBP1 HDAC6 HRAS INHBB KRAS OGT PGGT1B PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2	12 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B BMPR2 FNTA IGSF1 INHA INHBA INHBC TDGF1
Entrez ID		2339	3625
HPRD ID		00607	00934
Ensembl ID		ENSG00000168522	ENSG00000163083
Uniprot IDs		P49354	P09529
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?
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