SRGAP2 and EXOC1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
193

Data Source:
BioGRID (two hybrid)

		SRGAP2	EXOC1
Description		SLIT-ROBO Rho GTPase activating protein 2	exocyst complex component 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Lamellipodium Dendritic Spine Head Postsynaptic Membrane Phagocytic Vesicle	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Flemming Body Cytoplasmic Side Of Apical Plasma Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Lamellipodium Assembly Involved In Ameboidal Cell Migration Signal Transduction Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of GTPase Activity Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Death Dendritic Spine Development Negative Regulation Of Neuron Migration	Exocytosis Golgi To Plasma Membrane Transport Protein Transport Regulation Of Macroautophagy Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Secretion Defense Response To Virus
Pathways		Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Asthma ( 32296059) Cholesterol and Triglycerides ( 23031429) Refractive error ( 32231278) Type 2 diabetes ( 30297969)	Cerebrospinal P-tau181p levels ( 28247064) Cervical cancer ( 23817570) Daytime sleep phenotypes ( 27126917) Urinary albumin excretion ( 32277301) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: DISC1 EXOC1 FASLG ROBO1 YWHAG	29 interacting genes: ATG14 CCDC88A CCDC93 CCHCR1 CCSER2 CDC5L CEP295 COLEC12 DISC1 DST KANSL1 KDM1A LUC7L2 MACF1 MTNR1A NUF2 NUP54 RALA RB1CC1 RESF1 RUBCN SFR1 SH3BP5 SNAPIN SPTAN1 SRGAP2 SYBU TRAF3IP1 TRIO
Entrez ID		23380	55763
HPRD ID		18520	07615
Ensembl ID		ENSG00000266028	ENSG00000090989
Uniprot IDs		A0A075B7B5 B4DFE5 B7Z3G4 B7ZM87 O75044	A0A024RDA1 A1LT29 Q9NV70
PDB IDs		2DL8 4RTT 4RUG 5I6J 5I6R 5I7D
Enriched GO Terms of Interacting Partners?
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