SRGAP2

Description		SLIT-ROBO Rho GTPase activating protein 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Lamellipodium Dendritic Spine Head Postsynaptic Membrane Phagocytic Vesicle
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Lamellipodium Assembly Involved In Ameboidal Cell Migration Signal Transduction Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of GTPase Activity Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Death Dendritic Spine Development Negative Regulation Of Neuron Migration
Pathways		Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Asthma ( 32296059) Cholesterol and Triglycerides ( 23031429) Refractive error ( 32231278) Type 2 diabetes ( 30297969)
Interacting Genes		5 interacting genes: DISC1 EXOC1 FASLG ROBO1 YWHAG
Entrez ID		23380
HPRD ID		18520
Ensembl ID		ENSG00000266028
Uniprot IDs		A0A075B7B5 B4DFE5 B7Z3G4 B7ZM87 O75044
PDB IDs		2DL8 4RTT 4RUG 5I6J 5I6R 5I7D
Enriched GO Terms of Interacting Partners?
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