FLOT2 and CAV2

Number of citations of the paper that reports this interaction (PubMedID 10212252)
54

Data Source:
HPRD (in vivo)

		FLOT2	CAV2
Description		flotillin 2	caveolin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Uropod Acrosomal Membrane Endosome Plasma Membrane Caveola Adherens Junction Focal Adhesion Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Endocytic Vesicle Cortical Actin Cytoskeleton Cytoplasmic Vesicle Vesicle Dendrite Cytoplasm Intracellular Membrane-bounded Organelle Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Anchored Component Of Presynaptic Active Zone Membrane	Golgi Membrane Acrosomal Membrane Caveolar Macromolecular Signaling Complex Nucleus Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Transport Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Protein-containing Complex Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Molecular Adaptor Activity Scaffold Protein Binding
	Biological Process	Membrane Raft Assembly Cell Adhesion Epidermis Development Negative Regulation Of Gene Expression Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Toll-like Receptor 3 Signaling Pathway Protein Localization To Plasma Membrane Raft Regulation Of Myoblast Differentiation Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Plasma Membrane Anterograde Dendritic Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Establishment Of T Cell Polarity	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Vesicle Fusion Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Mitotic Nuclear Division Insulin Receptor Signaling Pathway Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Process Vesicle Docking Skeletal Muscle Fiber Development Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Dopamine Receptor Signaling Pathway Caveola Assembly Basement Membrane Organization
Pathways		RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RND3 GTPase cycle RND1 GTPase cycle	Extra-nuclear estrogen signaling
Drugs
Diseases
GWAS		Declining hemoglobin trajectory in blood donors ( 33491795) Mean corpuscular hemoglobin ( 29403010) Red blood cell count ( 27863252)	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Atrial fibrillation ( 30061737 29892015) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105 20835238) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 28073927) Ischemic stroke (cardioembolic) ( 29531354) P wave duration ( 28794112) Pancreatic ductal adenocarcinoma ( 33975060) PR interval ( 29127183 30046033 32439900 20062060 25035420) Refractive error ( 32231278) TPE interval (resting) ( 32386560)
Interacting Genes		11 interacting genes: APP CAV1 CAV2 DXO FLOT1 FYN HGS MAGEB4 NMNAT1 SPATA24 UBC	13 interacting genes: CAV1 CSNK2A1 DNAJA1 DRD1 EGFR FLOT2 FOXP2 GOLGB1 MALL NCK1 RASA1 SDCBP SRC
Entrez ID		2319	858
HPRD ID		00580	03029
Ensembl ID		ENSG00000132589	ENSG00000105971
Uniprot IDs		A0A024QZ62 J3QLD9 Q14254 Q6FG43 Q9BTI6	P51636 Q53X57
PDB IDs
Enriched GO Terms of Interacting Partners?
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