FLOT2 and NMNAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		FLOT2	NMNAT1
Description		flotillin 2	nicotinamide nucleotide adenylyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Uropod Acrosomal Membrane Endosome Plasma Membrane Caveola Adherens Junction Focal Adhesion Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Endocytic Vesicle Cortical Actin Cytoskeleton Cytoplasmic Vesicle Vesicle Dendrite Cytoplasm Intracellular Membrane-bounded Organelle Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Extracellular Exosome Glutamatergic Synapse Anchored Component Of Presynaptic Active Zone Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Protease Binding Protein Binding Ionotropic Glutamate Receptor Binding	Nicotinamide-nucleotide Adenylyltransferase Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Membrane Raft Assembly Cell Adhesion Epidermis Development Negative Regulation Of Gene Expression Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Toll-like Receptor 3 Signaling Pathway Protein Localization To Plasma Membrane Raft Regulation Of Myoblast Differentiation Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Plasma Membrane Anterograde Dendritic Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Establishment Of T Cell Polarity	Nucleotide Biosynthetic Process NAD Biosynthetic Process Response To Wounding Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic DNA Fragmentation ATP Generation From Poly-ADP-D-ribose
Pathways		RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RND3 GTPase cycle RND1 GTPase cycle	Nicotinate metabolism
Drugs			Nicotinamide Mononucleotide Deamido-Nad+
Diseases
GWAS		Declining hemoglobin trajectory in blood donors ( 33491795) Mean corpuscular hemoglobin ( 29403010) Red blood cell count ( 27863252)	Resting heart rate ( 27798624)
Interacting Genes		11 interacting genes: APP CAV1 CAV2 DXO FLOT1 FYN HGS MAGEB4 NMNAT1 SPATA24 UBC	20 interacting genes: APP BANP CCNC FLOT2 GORASP2 KPNA1 KPNA2 KPNA3 KPNA5 KPNA6 MSX1 NEK3 NFATC2IP NTRK2 PABPC4 PICK1 RNF4 SIK1 SIRT1 TDO2
Entrez ID		2319	64802
HPRD ID		00580	16369
Ensembl ID		ENSG00000132589	ENSG00000173614
Uniprot IDs		A0A024QZ62 J3QLD9 Q14254 Q6FG43 Q9BTI6	A0A024R4E1 B1AN62 Q9HAN9
PDB IDs			1GZU 1KKU 1KQN 1KQO 1KR2
Enriched GO Terms of Interacting Partners?
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