GGA2 and M6PR

Number of citations of the paper that reports this interaction (PubMedID 11387475)
134

Data Source:
HPRD (in vitro, two hybrid)

		GGA2	M6PR
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 2	mannose-6-phosphate receptor, cation dependent
Image
GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Endosome Membrane Clathrin-coated Vesicle Early Endosome Membrane	Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Membrane Transport Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Retromer Complex Binding
	Biological Process	Intracellular Protein Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes
Pathways		TBC/RABGAPs Amyloid fiber formation	Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS			SjÃ¶gren's syndrome ( 28076899) Total cholesterol levels ( 30275531) Type 1 diabetes ( 34127860)
Interacting Genes		36 interacting genes: ADRA2B AFTPH APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC FBXO7 GGA1 GGA3 GOLGA2 HGS HTT IGF2R LRP3 M6PR MAP3K1 MEMO1 PIN1 RABEP1 RABGEF1 RNF11 RTN4IP1 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TRIM23 VPS18	13 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4 TMPRSS15
Entrez ID		23062	4074
HPRD ID		09347	01106
Ensembl ID		ENSG00000103365	ENSG00000003056
Uniprot IDs		Q9UJY4	F5GX30 P20645
PDB IDs		1MHQ	1JUQ
Enriched GO Terms of Interacting Partners?
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