GGA2 and BACE2

Number of citations of the paper that reports this interaction (PubMedID 12135764)
47

Data Source:
BioGRID (unspecified method, pull down)

		GGA2	BACE2
Description		golgi associated, gamma adaptin ear containing, ARF binding protein 2	beta-secretase 2
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GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Endosome Membrane Clathrin-coated Vesicle Early Endosome Membrane	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane Dense Core Granule
	Molecular Function	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding	Aspartic-type Endopeptidase Activity Protein Binding
	Biological Process	Intracellular Protein Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport	Proteolysis Membrane Protein Ectodomain Proteolysis Peptide Hormone Processing Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Astrocyte Activation Amyloid-beta Metabolic Process
Pathways		TBC/RABGAPs Amyloid fiber formation
Drugs
Diseases
GWAS			Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356) Systemic lupus erythematosus ( 32771030)
Interacting Genes		36 interacting genes: ADRA2B AFTPH APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC FBXO7 GGA1 GGA3 GOLGA2 HGS HTT IGF2R LRP3 M6PR MAP3K1 MEMO1 PIN1 RABEP1 RABGEF1 RNF11 RTN4IP1 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TRIM23 VPS18	11 interacting genes: ABCA8 ACVR2A APP DIP2A GGA1 GGA2 ICOSLG LTC4S POFUT2 RAB27A UBASH3A
Entrez ID		23062	25825
HPRD ID		09347	05744
Ensembl ID		ENSG00000103365	ENSG00000182240
Uniprot IDs		Q9UJY4	Q9Y5Z0
PDB IDs		1MHQ	2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1
Enriched GO Terms of Interacting Partners?
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