JMJD1C and MT2A

Number of citations of the paper that reports this interaction (PubMedID 23455924)
46

Data Source:
BioGRID (two hybrid)

		JMJD1C	MT2A
Description		jumonji domain containing 1C	metallothionein 2A
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Transcription Coregulator Activity Protein Binding Chromatin DNA Binding Histone H3-methyl-lysine-9 Demethylase Activity Metal Ion Binding Thyroid Hormone Receptor Binding Dioxygenase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Blood Coagulation Histone H3-K9 Demethylation	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Detoxification Of Copper Ion Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion
Pathways		Factors involved in megakaryocyte development and platelet production	Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling
Drugs			Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Adult body size ( 32376654) Androgen levels ( 22936694) Apolipoprotein A1 levels ( 32203549) Arthritis (juvenile idiopathic) ( 22354554) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 29875488) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) CXCL5 levels ( 25147954) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Educational attainment ( 25201988) Eosinophil percentage of white cells ( 32888494) Fasting plasma glucose ( 31170924) FEV1 ( 30804560) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gallstone disease ( 30504769) General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 27863252) Household income (MTAG) ( 31844048) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory biomarkers (multivariate analysis) ( 33110245) Insulin-related traits (multivariate analysis) ( 32002517) Intelligence (MTAG) ( 29326435) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 33972514 22001757) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30061609) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Macular telangiectasia type 2 ( 33654266) Mean platelet volume ( 22139419 24026423 19820697 31194788 32888494 27863252 28031487) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet aggregation ( 20526338 29185836) Platelet count ( 26805783 22139419 24026423 23263863 32888494 22423221 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Prothrombin time ( 29403010) Schizophrenia ( 28991256) Serum alkaline phosphatase levels ( 31666285 29403010 33339817) Sex hormone-binding globulin levels ( 22829776) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549 28334899 32154731 29403010 33339817 31928498) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943 20686565) Type 2 diabetes ( 28406950 32499647) Urate levels ( 31578528) Vascular endothelial growth factor levels ( 26910538 27989323) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Walking pace ( 33128006) White blood cell count ( 27863252)
Interacting Genes		14 interacting genes: AR ESR2 GADD45A MT2A MYOM2 NUDT21 PPARG PSMC1 RNF168 RNF8 RXRA SRPK2 THRB TK1	20 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 STOM TNS2 USP25
Entrez ID		221037	4502
HPRD ID		05141	08863
Ensembl ID		ENSG00000171988	ENSG00000125148
Uniprot IDs		B7ZLC8 Q15652	P02795
PDB IDs		2YPD 5FZO	1MHU 2MHU
Enriched GO Terms of Interacting Partners?
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