MT2A and ECT2

Number of citations of the paper that reports this interaction (PubMedID 22990118)
49

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MT2A	ECT2
Description		metallothionein 2A	epithelial cell transforming 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Detoxification Of Copper Ion Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs		Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		20 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 STOM TNS2 USP25	39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2
Entrez ID		4502	1894
HPRD ID		08863	11860
Ensembl ID		ENSG00000125148	ENSG00000114346
Uniprot IDs		P02795	Q9H8V3
PDB IDs		1MHU 2MHU	3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?
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