UBR1 and ARL15

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBR1	ARL15
Description		ubiquitin protein ligase E3 component n-recognin 1	ADP ribosylation factor like GTPase 15
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	Molecular_function GTPase Activity Protein Binding GTP Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Biological_process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)	Adiponectin levels ( 20011104 22479202 31178129) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Alanine aminotransferase levels ( 33547301) Alcohol dependence (age at onset) ( 24962325) Alcoholic chronic pancreatitis ( 28754779) Apolipoprotein A1 levels ( 32203549) Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Body shape index ( 34021172) Brown vs. black hair color ( 30531825) Circulating leptin levels or type 2 diabetes ( 32341051) Coffee consumption ( 31046077) Coronary artery disease ( 29212778) Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting insulin ( 33402679 34059833) FEV1 ( 30804560) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glycine levels ( 30837465) HDL cholesterol ( 24097068 30275531 20686565) HDL cholesterol levels ( 32203549 28334899) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Lung function (FVC) ( 28166213 30804560) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolite levels ( 31628463) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Rheumatoid arthritis ( 23918589) Right lateral prefrontal cortical growth ( 29682794) Systolic blood pressure ( 27841878) Systolic blood pressure (dietary potassium intake interaction) ( 29212900) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531) Type 2 diabetes ( 24509480 30054458 29358691 30297969 30718926 28869590) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Urinary magnesium excretion ( 31993563) Urinary magnesium-to-creatinine ratio ( 29093028) Waist circumference adjusted for body mass index ( 34021172 25673412) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		31 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	14 interacting genes: B4GALT3 CCDC90B CRMP1 FUNDC2 GAPDH GRIPAP1 MEOX2 PDE6D PTN RPL8 TFG TUBB2A UBR1 UNC119
Entrez ID		197131	54622
HPRD ID		09342	12471
Ensembl ID		ENSG00000159459	ENSG00000185305
Uniprot IDs		Q8IWV7	Q9NXU5
PDB IDs		3NY1 5TDC
Enriched GO Terms of Interacting Partners?
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