UBR1 and PKNOX1

Number of citations of the paper that reports this interaction (PubMedID 33229537)
0

Data Source:
BioGRID (protein complementation assay)

		UBR1	PKNOX1
Description		ubiquitin protein ligase E3 component n-recognin 1	PBX/knotted 1 homeobox 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)	Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)
Interacting Genes		31 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	26 interacting genes: APP BLOC1S5 BORCS6 FAM110B FHL2 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 MEIS1 MPP3 MX2 NUP58 PAX6 PBX1 PBX2 PBX4 PCNT POU2F1 RFX3 TET2 TLX1 UBR1 VPS37C ZBTB3
Entrez ID		197131	5316
HPRD ID		09342	03653
Ensembl ID		ENSG00000159459	ENSG00000160199
Uniprot IDs		Q8IWV7	B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87
PDB IDs		3NY1 5TDC	1X2N
Enriched GO Terms of Interacting Partners?
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