UBR1 and ARL3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBR1	ARL3
Description		ubiquitin protein ligase E3 component n-recognin 1	ADP ribosylation factor like GTPase 3
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Spindle Microtubule Cytoplasmic Microtubule Cilium Microtubule Cytoskeleton Midbody Photoreceptor Connecting Cilium Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding GDP Binding GTPase Activating Protein Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway	Mitotic Cytokinesis Kidney Development Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Smoothened Signaling Pathway Small GTPase Mediated Signal Transduction Protein Transport Positive Regulation Of Microtubule Polymerization Intraciliary Transport Photoreceptor Cell Development Cilium Assembly Protein Localization To Cilium Protein Localization To Ciliary Membrane
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Trafficking of myristoylated proteins to the cilium
Drugs			2-(N-morpholino)ethanesulfonic acid Guanosine-5'-Diphosphate
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Hip circumference adjusted for BMI ( 34021172) Mean arterial pressure ( 30487518) Mean arterial pressure (long-term average) ( 28348047) Prostate cancer ( 23535732) Pulse pressure ( 30487518) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 27922604) Systolic blood pressure ( 30487518) Systolic blood pressure (long-term average) ( 28348047) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		31 interacting genes: ANXA3 ARL15 ARL3 ARL4D ATF3 BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NR3C1 NTAN1 NTAQ1 NUDT3 PKNOX1 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2	12 interacting genes: ARL2BP GOLGA4 LRIF1 PDE6D PTEN RP2 TBL1X TLE1 TP53 TUBA1A UBR1 UNC119
Entrez ID		197131	403
HPRD ID		09342	05260
Ensembl ID		ENSG00000159459	ENSG00000138175
Uniprot IDs		Q8IWV7	P36405
PDB IDs		3NY1 5TDC
Enriched GO Terms of Interacting Partners?
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