DR1 and YEATS2

Number of citations of the paper that reports this interaction (PubMedID 22939629)
326

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, biochemical)

		DR1	YEATS2
Description		down-regulator of transcription 1	YEATS domain containing 2
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GO Annotations	Cellular Component	Nucleoplasm Negative Cofactor 2 Complex RNA Polymerase II Transcription Regulator Complex	Mitotic Spindle
	Molecular Function	Core Promoter Sequence-specific DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Heterodimerization Activity	Protein Binding TBP-class Protein Binding Histone Binding Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Histone H3 Acetylation Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated
Pathways		HATs acetylate histones	HATs acetylate histones
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549 29403010 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urate levels ( 31578528)	Adult body size ( 32376654) Systolic blood pressure ( 30224653) Visceral fat ( 30942860)
Interacting Genes		9 interacting genes: DNMT3L DRAP1 NFIL3 NFYC POLE3 TBP XPO1 YEATS2 ZDHHC17	2 interacting genes: DR1 TBP
Entrez ID		1810	55689
HPRD ID		03284	07652
Ensembl ID		ENSG00000117505	ENSG00000163872
Uniprot IDs		Q01658 Q658N3	Q9ULM3
PDB IDs		1JFI	5IQL 5XNV 6LSD
Enriched GO Terms of Interacting Partners?
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