DR1 and DNMT3L

Number of citations of the paper that reports this interaction (PubMedID 24952347)
14

Data Source:
BioGRID (pull down)

		DR1	DNMT3L
Description		down-regulator of transcription 1	DNA methyltransferase 3 like
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GO Annotations	Cellular Component	Nucleoplasm Negative Cofactor 2 Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Cytosol
	Molecular Function	Core Promoter Sequence-specific DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Heterodimerization Activity	Protein Binding Enzyme Activator Activity Enzyme Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Histone H3 Acetylation Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly	DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Male Meiosis I Spermatogenesis DNA Methylation On Cytosine DNA Methylation Involved In Gamete Generation Negative Regulation Of Transcription, DNA-templated Stem Cell Differentiation Regulation Of Catalytic Activity Negative Regulation Of DNA Methylation Positive Regulation Of DNA Methylation
Pathways		HATs acetylate histones	DNA methylation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Triglyceride levels ( 32203549 29403010 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Urate levels ( 31578528)
Interacting Genes		9 interacting genes: DNMT3L DRAP1 NFIL3 NFYC POLE3 TBP XPO1 YEATS2 ZDHHC17	78 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PDZD4 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1
Entrez ID		1810	29947
HPRD ID		03284	09417
Ensembl ID		ENSG00000117505	ENSG00000142182
Uniprot IDs		Q01658 Q658N3	Q9UJW3
PDB IDs		1JFI	2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57 6KDA 6KDB 6KDL 6KDP 6KDT 6U8P 6U8V 6U8W 6U8X 6U90 6U91 6W89 6W8B 6W8D 6W8J
Enriched GO Terms of Interacting Partners?
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