ASXL1 and DEFB116

		ASXL1	DEFB116
Description		ASXL transcriptional regulator 1	defensin beta 116
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm PR-DUB Complex	Extracellular Region
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding
	Biological Process	Cell Morphogenesis Heart Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Lipid Storage Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Monoubiquitinated Histone H2A Deubiquitination Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Lung Saccule Development Glomerular Visceral Epithelial Cell Development	Defense Response To Bacterium Innate Immune Response
Pathways		UCH proteinases	Beta defensins Defensins
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)	Prudent dietary pattern ( 28644415) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		17 interacting genes: APP DEFB115 DEFB116 FASN FOXK1 FOXK2 GOLGA6L9 H1-2 ID1 IRAG1 MRPS7 NCOA6 POLD1 SRM SRPK1 STAT3 UBC	2 interacting genes: ASXL1 POFUT1
Entrez ID		171023	245930
HPRD ID		16516	19020
Ensembl ID		ENSG00000171456	ENSG00000215545
Uniprot IDs		Q498B9 Q8IXJ9	Q30KQ4
PDB IDs
Enriched GO Terms of Interacting Partners?
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