ASXL1 and FOXK1

Number of citations of the paper that reports this interaction (PubMedID 27705803)
84

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)

		ASXL1	FOXK1
Description		ASXL transcriptional regulator 1	forkhead box K1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm PR-DUB Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding 14-3-3 Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cell Morphogenesis Heart Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Lipid Storage Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Monoubiquitinated Histone H2A Deubiquitination Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Lung Saccule Development Glomerular Visceral Epithelial Cell Development	Negative Regulation Of Transcription By RNA Polymerase II Cellular Glucose Homeostasis Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Negative Regulation Of Autophagy Regulation Of Glucose Metabolic Process Cell Differentiation Response To Starvation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Canonical Glycolysis
Pathways		UCH proteinases	UCH proteinases
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908) Red cell distribution width ( 32888494)	Apolipoprotein A1 levels ( 32203549) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 30224653) Disease progression in age-related macular degeneration ( 29346644) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Heel bone mineral density ( 30598549) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695)
Interacting Genes		17 interacting genes: APP DEFB115 DEFB116 FASN FOXK1 FOXK2 GOLGA6L9 H1-2 ID1 IRAG1 MRPS7 NCOA6 POLD1 SRM SRPK1 STAT3 UBC	4 interacting genes: ASXL1 IRF2 PTEN SRF
Entrez ID		171023	221937
HPRD ID		16516	18750
Ensembl ID		ENSG00000171456	ENSG00000164916
Uniprot IDs		Q498B9 Q8IXJ9	P85037
PDB IDs
Enriched GO Terms of Interacting Partners?
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