COL5A2 and DDR1

Number of citations of the paper that reports this interaction (PubMedID 9659900)
151

Data Source:
HPRD (in vivo)

		COL5A2	DDR1
Description		collagen type V alpha 2 chain	discoidin domain receptor tyrosine kinase 1
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type V Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength SMAD Binding Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Skeletal System Development Ossification Extracellular Matrix Organization Collagen Fibril Organization Skin Development Eye Morphogenesis Cellular Response To Amino Acid Stimulus Negative Regulation Of Endodermal Cell Differentiation	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Embryo Implantation Lactation Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Smooth Muscle Cell Migration Positive Regulation Of Kinase Activity Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion Axon Development Neuron Projection Extension
Pathways		Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization	Non-integrin membrane-ECM interactions
Drugs			Imatinib Fostamatinib Pralsetinib
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Haemorrhoidal disease ( 33888516) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Age-related macular degeneration ( 23455636) Arterial stiffness index ( 31235810) Autism spectrum disorder or schizophrenia ( 28540026) HIV-1 control ( 20041166) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Microalbuminuria in type 1 diabetes ( 31537649) Response to hepatitis B vaccine ( 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking initiation (ever regular vs never regular) ( 30679032) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: BMP1 DDR1	20 interacting genes: BEND5 BRD2 COL11A1 COL2A1 COL3A1 COL5A2 ERBB2 FRS2 MAPK6 NCK2 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR UBQLN2
Entrez ID		1290	780
HPRD ID		00366	02678
Ensembl ID		ENSG00000204262	ENSG00000204580
Uniprot IDs		P05997	A0A024RCJ0 A0A024RCL1 A0A024RCQ1 A0A0A0MSX3 Q08345 Q96T61 Q96T62
PDB IDs		1A9A	3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX 6BRJ 6BSD 6FEW 6FEX 6FIL 6FIN 6FIO 6FIQ 6GWR 6HP9 6Y23 7BCM 7BE6
Enriched GO Terms of Interacting Partners?
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