COL5A2 and BMP1

Number of citations of the paper that reports this interaction (PubMedID 11741999)
31

Data Source:
HPRD (in vivo)

		COL5A2	BMP1
Description		collagen type V alpha 2 chain	bone morphogenetic protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type V Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Golgi Apparatus Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength SMAD Binding Metal Ion Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	Skeletal System Development Ossification Extracellular Matrix Organization Collagen Fibril Organization Skin Development Eye Morphogenesis Cellular Response To Amino Acid Stimulus Negative Regulation Of Endodermal Cell Differentiation	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Multicellular Organism Development Cell Differentiation Collagen Fibril Organization Positive Regulation Of Cartilage Development
Pathways		Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization	Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Haemorrhoidal disease ( 33888516) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Myocardial infarction ( 33532862) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		2 interacting genes: BMP1 DDR1	18 interacting genes: ADRA1A CHRD CLIP2 COL1A1 COL5A1 COL5A2 COL7A1 CST7 DST GEM HSPG2 LAMA3 LAMB3 LAMC2 PTPRZ1 TP53 TWSG1 YLPM1
Entrez ID		1290	649
HPRD ID		00366	00209
Ensembl ID		ENSG00000204262	ENSG00000168487
Uniprot IDs		P05997	P13497
PDB IDs		1A9A	3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ
Enriched GO Terms of Interacting Partners?
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