BMP1 and COL7A1

Number of citations of the paper that reports this interaction (PubMedID 11986329)
32

Data Source:
HPRD (in vivo)

		BMP1	COL7A1
Description		bone morphogenetic protein 1	collagen type VII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Extracellular Region Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Identical Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Multicellular Organism Development Cell Differentiation Collagen Fibril Organization Positive Regulation Of Cartilage Development	Cell Adhesion Epidermis Development Negative Regulation Of Endopeptidase Activity Endodermal Cell Differentiation
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures COPII-mediated vesicle transport Integrin cell surface interactions Anchoring fibril formation Laminin interactions Laminin interactions Cargo concentration in the ER Collagen chain trimerization
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Myocardial infarction ( 33532862) Waist-to-hip ratio adjusted for BMI ( 28552196)	Age at first sexual intercourse ( 27089180) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Bone fracture in osteoporosis ( 28580392) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		18 interacting genes: ADRA1A CHRD CLIP2 COL1A1 COL5A1 COL5A2 COL7A1 CST7 DST GEM HSPG2 LAMA3 LAMB3 LAMC2 PTPRZ1 TP53 TWSG1 YLPM1	16 interacting genes: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MIA3 MMP2 NPHP3 SHKBP1 THBS1 ZC3H7A
Entrez ID		649	1294
HPRD ID		00209	00358
Ensembl ID		ENSG00000168487	ENSG00000114270
Uniprot IDs		P13497	Q02388 Q59F16
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ
Enriched GO Terms of Interacting Partners?
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