CLRN3 and DOCK1

		CLRN3	DOCK1
Description		clarin 3	dedicator of cytokinesis 1
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process		Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Epithelial Cell Migration Regulation Of Catalytic Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways			Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Parkinson's disease (motor and cognition) ( 22658654)	Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)
Interacting Genes		3 interacting genes: DOCK1 MMP21 ZDHHC17	18 interacting genes: ADAM12 BCAR1 C10orf90 CLRN3 CRK CYTH2 ELMO1 ELMO2 MMP21 NCK2 PRKACA PSAT1 RAC1 RHOG STX16 TAMALIN TLK2 WASF2
Entrez ID		119467	1793
HPRD ID		14553	03240
Ensembl ID		ENSG00000180745	ENSG00000150760
Uniprot IDs		Q8NCR9	A0A2X0U2H5 B2RUU3 Q14185
PDB IDs			3L4C
Enriched GO Terms of Interacting Partners?
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