DOCK1 and ELMO1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		DOCK1	ELMO1
Description		dedicator of cytokinesis 1	engulfment and cell motility 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Guanyl-nucleotide Exchange Factor Complex	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding
	Biological Process	Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Epithelial Cell Migration Regulation Of Catalytic Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Phagocytosis, Engulfment Apoptotic Process Actin Filament Organization Cell Migration Rac Protein Signal Transduction Actin Cytoskeleton Organization Cell Motility Regulation Of Catalytic Activity
Pathways		Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	Nef and signal transduction Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)	Alzheimer's disease (cognitive decline) ( 23535033) Anticoagulant levels ( 22216198) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Body fat mass ( 28552196) Breast size ( 22747683) Celiac disease ( 22057235 20190752 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Cerebrospinal fluid AB1-42 levels ( 28247064) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 31562340) Inflammatory skin disease ( 25574825) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) QT interval ( 20031603) Response to treatment for acute lymphoblastic leukemia ( 19176441) Rheumatoid arthritis ( 23143596) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 30572963) Trunk fat mass ( 28552196) Type 2 diabetes nephropathy ( 17653210) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		18 interacting genes: ADAM12 BCAR1 C10orf90 CLRN3 CRK CYTH2 ELMO1 ELMO2 MMP21 NCK2 PRKACA PSAT1 RAC1 RHOG STX16 TAMALIN TLK2 WASF2	10 interacting genes: ADGRB1 ADGRB3 APBB1 DOCK1 DOCK2 FGD1 HCK RHOG TRIM54 ZNF398
Entrez ID		1793	9844
HPRD ID		03240	12102
Ensembl ID		ENSG00000150760	ENSG00000155849
Uniprot IDs		A0A2X0U2H5 B2RUU3 Q14185	A4D1X5 Q92556
PDB IDs		3L4C	2RQR 2VSZ 3A98 6JPP 6TGB 6TGC
Enriched GO Terms of Interacting Partners?
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