DOCK1 and MMP21

		DOCK1	MMP21
Description		dedicator of cytokinesis 1	matrix metallopeptidase 21
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Guanyl-nucleotide Exchange Factor Complex	Extracellular Space Extracellular Matrix
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Positive Regulation Of Epithelial Cell Migration Regulation Of Catalytic Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Hematopoietic Progenitor Cell Differentiation Proteolysis Determination Of Left/right Symmetry Extracellular Matrix Organization Collagen Catabolic Process Coronary Vasculature Development Determination Of Heart Left/right Asymmetry
Pathways		Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs			Marimastat
Diseases
GWAS		Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)	Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: ADAM12 BCAR1 C10orf90 CLRN3 CRK CYTH2 ELMO1 ELMO2 MMP21 NCK2 PRKACA PSAT1 RAC1 RHOG STX16 TAMALIN TLK2 WASF2	4 interacting genes: CLRN3 DOCK1 FOXI2 NPS
Entrez ID		1793	118856
HPRD ID		03240	07003
Ensembl ID		ENSG00000150760	ENSG00000154485
Uniprot IDs		A0A2X0U2H5 B2RUU3 Q14185	Q8N119
PDB IDs		3L4C
Enriched GO Terms of Interacting Partners?
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