GCN1 and SLC2A1

		GCN1	SLC2A1
Description		GCN1 activator of EIF2AK4	solute carrier family 2 member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Ribosome Polysome Membrane	Golgi Membrane Photoreceptor Inner Segment Female Pronucleus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Caveola Intercalated Disc Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc Midbody Cortical Actin Cytoskeleton Sarcolemma Melanosome Extracellular Exosome Blood Microparticle Presynapse
	Molecular Function	RNA Binding Translation Factor Activity, RNA Binding Protein Kinase Regulator Activity Protein Kinase Binding Ribosome Binding Cadherin Binding	Long-chain Fatty Acid Transporter Activity Glucose Transmembrane Transporter Activity Protein Binding Kinase Binding Dehydroascorbic Acid Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity Protein Self-association D-glucose Transmembrane Transporter Activity
	Biological Process	Translation Regulation Of Translation Positive Regulation Of Kinase Activity Cellular Response To Amino Acid Starvation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Response To Leucine Starvation	Response To Hypoxia Central Nervous System Development Female Pregnancy Long-chain Fatty Acid Import Across Plasma Membrane L-ascorbic Acid Metabolic Process Cerebral Cortex Development Response To Insulin Cellular Response To Glucose Starvation Xenobiotic Transport Photoreceptor Cell Maintenance Protein-containing Complex Assembly Dehydroascorbic Acid Transport Cellular Response To Mechanical Stimulus Cellular Hyperosmotic Response Glucose Import Across Plasma Membrane Transport Across Blood-brain Barrier Response To Thyroglobulin Triiodothyronine Glucose Transmembrane Transport
Pathways		Response of EIF2AK4 (GCN2) to amino acid deficiency	Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis
Drugs			Resveratrol Carboxymethylcellulose
Diseases
GWAS			Birth weight ( 31043758) Cardiac hypertrophy ( 21348951) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: MYC SLC2A1 SUMO2 YWHAQ	24 interacting genes: ADNP BMP8B CALR CANX CCR2 CDKN1C CHRNB4 COPS6 FAAH GAPDH GCN1 GIPC1 GPR35 HSPB2 LTB4R2 PDIA3 PTK2B PTPRU SMAP2 STOM SUMO1 UBE2I VHL ZRSR2
Entrez ID		10985	6513
HPRD ID		16127	00683
Ensembl ID		ENSG00000089154	ENSG00000117394
Uniprot IDs		Q92616	P11166 Q59GX2
PDB IDs			1SUK 4PYP 5EQG 5EQH 5EQI 6THA
Enriched GO Terms of Interacting Partners?
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