GLRX3 and PRKD2

Number of citations of the paper that reports this interaction (PubMedID 15231748)
99

Data Source:
BioGRID (two hybrid)

		GLRX3	PRKD2
Description		glutaredoxin 3	protein kinase D2
Image
GO Annotations	Cellular Component	Nucleus Cytosol Cell Cortex Z Disc Dendrite	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding Glutathione Oxidoreductase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of The Force Of Heart Contraction Cellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy [2Fe-2S] Cluster Assembly Protein Maturation By Iron-sulfur Cluster Transfer	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Protein Phosphorylation Cell Adhesion Cell Death Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sphingolipid Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Endothelial Tube Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Iron uptake and transport	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Alcohol dependence ( 26365420) Colorectal cancer ( 34062886) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HIV-1 susceptibility ( 21160409) Mean corpuscular volume ( 32888494) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Sleep end time ( 33075057) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)	Aspartate aminotransferase levels ( 33547301) Chronic lymphocytic leukemia ( 18758461 28165464) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Post bronchodilator FEV1 ( 26634245) Primary sclerosing cholangitis ( 23603763 27992413)
Interacting Genes		101 interacting genes: ADAMTSL3 ADAMTSL4 ALKBH3 BCL6 BOLA1 BOLA2 BOLA2B BOLA3 CA9 CBLB CCHCR1 CERCAM CGGBP1 CIAPIN1 COL8A1 DANCR EFEMP2 ERBB2 FAM118A FRA10AC1 GATA1 GMCL1 GNG13 GRN HEXD HSD3B7 IHO1 IKZF1 IL10 IRX6 KLHDC9 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2D LNX1 LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI METAP1 MOXD1 NADK NOTCH2NLA NTF4 OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ PRKD2 RCOR3 RECK REL RGS20 SMARCC1 SOX7 STAU1 STRA6 TCF4 TCL1B TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF124 ZNF148 ZNF23 ZNF426 ZNF490 ZNF512B ZNF544 ZNF774	18 interacting genes: ATP1A3 CASK DST GLRX3 GORASP1 GRIP1 HDAC7 HEY1 IFNAR1 MTF2 PDLIM7 PFDN1 PSG3 RARB RRBP1 RXRA SNRNP70 TGOLN2
Entrez ID		10539	25865
HPRD ID		10153	09523
Ensembl ID		ENSG00000108010	ENSG00000105287
Uniprot IDs		A0A140VJK1 O76003	Q9BZL6
PDB IDs		2DIY 2WZ9 2YAN 3ZYW	2COA 3BGM 4NNX 4NNY
Enriched GO Terms of Interacting Partners?
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