GLRX3 and ADAMTSL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GLRX3	ADAMTSL3
Description		glutaredoxin 3	ADAMTS like 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cell Cortex Z Disc Dendrite	Extracellular Region Extracellular Matrix Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding Glutathione Oxidoreductase Activity	Metalloendopeptidase Activity Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Cellular Iron Ion Homeostasis Negative Regulation Of Cardiac Muscle Hypertrophy [2Fe-2S] Cluster Assembly Protein Maturation By Iron-sulfur Cluster Transfer	Extracellular Matrix Organization
Pathways		Iron uptake and transport	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Alcohol dependence ( 26365420) Colorectal cancer ( 34062886) Copper levels ( 26025379) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HIV-1 susceptibility ( 21160409) Mean corpuscular volume ( 32888494) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Sleep end time ( 33075057) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Appendicular lean mass ( 28724990) Asthma ( 34103634 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Body size at age 10 ( 32376654) Childhood body mass index ( 33045005) Chronic obstructive pulmonary disease ( 30804561 33909500) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 21998595 28552196 20881960 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 33713608 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Hip index ( 34021172) Lean body mass ( 28724990) Optic disc size ( 31809533) Pulse pressure ( 30224653) Schizophrenia ( 28991256 25056061 29483656 30285260) Spine bone size ( 31053729) Waist circumference ( 26785701) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 34021172 26785701 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		101 interacting genes: ADAMTSL3 ADAMTSL4 ALKBH3 BCL6 BOLA1 BOLA2 BOLA2B BOLA3 CA9 CBLB CCHCR1 CERCAM CGGBP1 CIAPIN1 COL8A1 DANCR EFEMP2 ERBB2 FAM118A FRA10AC1 GATA1 GMCL1 GNG13 GRN HEXD HSD3B7 IHO1 IKZF1 IL10 IRX6 KLHDC9 KRT31 KRT38 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2D LNX1 LNX2 LRIG1 MAP3K3 MAPK6 MAPKBP1 MDFI METAP1 MOXD1 NADK NOTCH2NLA NTF4 OLFM3 PCSK5 PFDN5 PLEKHG4B PLSCR1 PRKCQ PRKCZ PRKD2 RCOR3 RECK REL RGS20 SMARCC1 SOX7 STAU1 STRA6 TCF4 TCL1B TLE5 TMEM25 TRAF1 TRIM36 TRIM42 UGP2 ZBTB44 ZNF124 ZNF148 ZNF23 ZNF426 ZNF490 ZNF512B ZNF544 ZNF774	21 interacting genes: ALPK3 BNC1 CYSRT1 EFL1 GLRX3 GOLGA2P10 HDGFL3 IDH3A KRT40 KRTAP1-1 KRTAP10-3 KRTAP10-6 KRTAP10-8 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP3-2 KRTAP5-7 MDFI NOTCH2NLA RAMAC
Entrez ID		10539	57188
HPRD ID		10153	12426
Ensembl ID		ENSG00000108010	ENSG00000156218
Uniprot IDs		A0A140VJK1 O76003	P82987
PDB IDs		2DIY 2WZ9 2YAN 3ZYW
Enriched GO Terms of Interacting Partners?
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