PRKD2 and HDAC7

Number of citations of the paper that reports this interaction (PubMedID 15623513)
63

Data Source:
HPRD (in vivo, in vitro)

		PRKD2	HDAC7
Description		protein kinase D2	histone deacetylase 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	Chromatin Binding Transcription Corepressor Activity Protein Kinase C Binding Protein Binding SUMO Transferase Activity Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Metal Ion Binding 14-3-3 Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Protein Phosphorylation Cell Adhesion Cell Death Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sphingolipid Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Endothelial Tube Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase D Signaling Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Protein Deacetylation Cell-cell Junction Assembly Protein Sumoylation Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Sphingolipid de novo biosynthesis	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs			Trichostatin A Belinostat Panobinostat
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Chronic lymphocytic leukemia ( 18758461 28165464) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Heel bone mineral density ( 30598549) Post bronchodilator FEV1 ( 26634245) Primary sclerosing cholangitis ( 23603763 27992413)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 30929738 32296059) Asthma (adult onset) ( 31036433 30929738) Bipolar disorder ( 31043756) Body shape index ( 34021172) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Diastolic blood pressure ( 27841878) Fasting insulin ( 34059833) Haemorrhoidal disease ( 33888516) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Urate levels ( 23263486) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: ATP1A3 CASK DST GLRX3 GORASP1 GRIP1 HDAC7 HEY1 IFNAR1 MTF2 PDLIM7 PFDN1 PSG3 RARB RRBP1 RXRA SNRNP70 TGOLN2	59 interacting genes: ACOT11 ACTN4 ANTKMT ARID5A BCL6 BRWD1 C3orf36 CALCOCO2 CASP8 CDC42 CENPQ DDIT4L EDNRA EGFR ESM1 GNG12 GNMT GOLGA6L9 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 KLF16 KRBA2 LDB2 MARK2 MARK3 MEF2A MEF2C MEOX2 MIEN1 NCOR2 NME4 NRIP2 PATJ PHC2 PPARD PPP1R16A PRKD1 PRKD2 RAC1 RAC2 RAC3 REL RIPPLY1 RRAS2 RUNX2 SIN3A SLC16A3 SOGA1 TIAF1 UBE2I UBL3 YPEL3 YWHAG YWHAQ ZBTB16
Entrez ID		25865	51564
HPRD ID		09523	09133
Ensembl ID		ENSG00000105287	ENSG00000061273
Uniprot IDs		Q9BZL6	Q8WUI4
PDB IDs		2COA 3BGM 4NNX 4NNY	3C0Y 3C0Z 3C10 3ZNR 3ZNS
Enriched GO Terms of Interacting Partners?
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